HORDB

ID: hor002022
Uniprot ID: Q28588
Protein name: Progonadoliberin-1
Gene name: GNRH1
Organism: Ovis aries (Sheep)
Family: GnRH family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005183 gonadotropin hormone-releasing hormone activity
GO BP: GO:0007165 signal transduction; GO:0033684 regulation of luteinizing hormone secretion; GO:0046880 regulation of follicle-stimulating hormone secretion
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Mechanism: NA
Cross BBB: NA
Target: GNRHR
Target Unid: P32237
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q28588-F1.pdb

hor002022_AF2.pdb

hor002022_ESM.pdb

Mass:	789819	Formula:	C298H476N88O90S3
Absent amino acids:	MT	Common amino acids:	EKLSAGIPQV
pI:	7.44	Basic residues:	11
Polar residues:	15	Hydrophobic residues:	19
Hydrophobicity:	-56.56	Boman Index:	-11869
Half-Life / Aliphatic Index:	0.8 hour	Aliphatic Index:	83.11
Instability Index:	6390.66	Extinction Coefficient cystines:	7115
Absorbance 280nm:	118.58